Each year has an explanation and legend to the logs. We have started the NSS log at 1930 with all trailer numbers and then combinations of trailer and posters starting in 1940. This system worked well until computers began catching up and in 1977, NSS changed the variation they were putting on the posters BACK to the initial way of 2 numbers and then 4 numbers. They settled with a slight variation of putting the 2 numbers (the year) and then a slash (/) and then the individual number without the zeros in between. In 19, NSS tested several variations to try to make the posters easier to identify in the warehouse. This was the standard way that the number was shown until they started with the posters in 1940.
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The initial number was a series of 2 numbers (which is the year) and then 4 numbers which would be that specific title. The NSS numbers that were used were created by title so the same number was used for both trailers and all assessories. More info on this see the NSS history section. Consequently, a couple of the studios will have a few releases through NSS BEFORE the start date listed below. There were a few studios that initially went with NON-exclusive contracts with NSS. Listed here is when the major studios signed EXCLUSIVE contracts with NSS for poster distribution. In 1939, Paramount approached NSS to take over their entire poster distribution under certain circumstances. This experiment failed as did several others that the studios tried. Set up for trailers, they were in approached to also handle specialty studio advertising Because they already had a national distribution In 1935 National Screen ventured into posters by providing aįew specialty posters. This number was their way of keeping track of the different trailers even when the titles were very similar. By 1930, they had created a unique numbering system for each title that they handled. All rights reserved.National Screen Service actually started in 1920 with Mutational and structural changes contribute to tumour heterogeneity at diagnosis and progression.Ĭlonal evolution Head and neck cancer MLL2 PIK3CA Subclonal selection TP53 Tumour heterogeneity.Ĭopyright © 2018 Elsevier Ltd. Copy number analyses revealed additional changes that were not detected by mutational analyses. Targeted MPS demonstrated substantial heterogeneity at the time of diagnosis and a complex pattern of evolution during disease progression in head and neck cancer. Structural genomic changes over time were also present in 7 of 12 (60%) evaluable patients with metachronous metastases. This pattern was associated with a shorter time to distant metastasis, compared with a pattern of punctuated evolution. We observed a branched pattern of evolution in 31.6% of the analysed patients.
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After pathological analyses, these samples were analysed using a targeted massively parallel sequencing (MPS) panel of 257 genes known to be recurrently mutated in head and neck cancer plus a genome-wide SNP-set.ĭespite histological diagnosis of distant metastasis, no corresponding mutation in the supposed metastases was found in two of 23 (8.6%) evaluable patients suggesting a primary tumour of the lung instead of a distant metastasis of head and neck cancer. We identified 26 patients with material from the primary tumour, the distant metastasis after curative first-line treatment and a germline sample for analysis of clonal evolution. Nevertheless, the clonal architecture in distant relapse of head and neck cancer is fairly unknown.įor this project, we analysed a cohort of 386 patients within the Austrian Registry of head and neck cancer. Tumour heterogeneity and clonal evolution within a cancer patient are deemed responsible for relapse in malignancies and present challenges to the principles of targeted therapy, for which treatment modality is often decided based on the molecular pathology of the primary tumour.
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